Development of MR Molecular Imaging Nanoprobe Using MNCs

In this study, we tried to develop nanoprobe for molecular magnetic resonance (MR) imaging using magnetic nanoclusters (MNC). MNCs for magnetic resonance imaging were synthesized by thermal decomposition. The size of the synthesized MNC was confirmed to be 73 ± 32.4 nm. Cytotoxicity test of the synthesized MNCs showed that the cell state of about 80% or more did not change in all the treatment ranges and cell survival rate was high even though the MNCs were injected. MNC was injected intravenously into the tail vein of nude mouse, images were observed as time goes by. As a result, it was found that enhancement of the contrast was confirmed in xenograft mice model using MNC. These results will contribute to clinical application and related research through magnetic nanocluster in the future.